ABSTRACT
Genitourinary tract infections are some of the most common infections in females. These problems are a challenge in terms of diagnosis and treatment. The present study was conducted to evaluate the prescribing pattern in three of the most common types of female genitourinary tract infections.METHODSA prospective and observational study was conducted on genitourinary tract infections in female patients at the gynaecology outpatient department in a tertiary care university hospital.RESULTSMajority of the infected female patients were in 26 - 35 years age group (31.8%) followed by 36 - 45 years age group (25.9%). The common infection noticed was urinary tract infection (42.2%), followed by pelvic inflammatory disease (32.2%) and vaginitis (25.5%) in infected female patients. The types of antibiotics prescribed for urinary tract infection were aminoglycosides, fluoroquinolones, cephalosporins and penicillins. The commonly prescribed antibiotics for pelvic inflammatory disease were tetracyclines, azoles, fluoroquinolones and cephalosporins, and for vaginitis azoles and aminoglycosides. The most commonly prescribed class of antibiotics for urinary tract infection, pelvic inflammatory disease and vaginitis were fluoroquinolones (11.8%), azoles (11.8%) and aminoglycosides (15.7%), respectively. Oral route was the preferred mode of administration (71%), followed by rectal (suppositories, 17.2%) and topical (cream, 11.8%).CONCLUSIONSYoung married women in this urban Indian community have a high prevalence of genitourinary tract infections but seldom seek treatment. Education and outreach are needed to reduce the stigma, embarrassment and lack of knowledge related to genitourinary tract infections
ABSTRACT
Administration of a single dose of doxorubicin (DOX) (7.5 mg/kg, iv) produces cardiotoxicity, manifested biochemically by significant decrease in blood glutathione (GSH) and tissue GSH along with elevated levels of serum lactate dehydrogenase (LDH) and serum creatine phosphokinase (CPK). In addition, cardiotoxicity was further confirmed by significant increase in lipid peroxides expressed as malondialdehyde (MDA, secondary indicator of lipid peroxidation), tissue catalase and tissue superoxide dismutase (SOD). Administration of A. vera gel (100 and 200 mg/kg) orally for 10 days produced a significant protection against cardiotoxicity induced by DOX evidenced by significant reductions in serum LDH, serum CPK, cardiac lipid peroxides, tissue catalase and tissue SOD along with increased levels of blood and tissue GSH. The results revealed that A. vera gel produced a dose dependent protection against DOX induced cardiotoxiaty.